![]() ![]() However, the underlying neurobiological mechanism is still unclear, and there are still challenges in the treatment for this group of population. With the high incidence rate and suicide risk, NSSI has been attracted widespread attention among scholars. It has been further indicated that NSSI should be considered as a specific predictor of suicide ( 6). According to the DSM-V, subjects with NSSI would be engaged in self-injury behavior five or more days within the past year to gain relief from the negative feelings or cognitive states ( 5). Non-Suicidal Self-Injury (NSSI) is defined as deliberately damaging one’s own body without intention to die ( 4). Additionally, MDD has a significant association with self-injury and suicide ( 3). ![]() And the adolescent depression could also increase the risk of depression later in the adulthood ( 2). As a transitional stage from childhood to adulthood, the period of adolescence has a high prevalence of the psychiatric disorders such as MDD. Major depressive disorder (MDD) is a common psychiatric disorder that is characterized by persistent low mood and loss of interest or pleasure in all activities, and these symptoms could finally lead to clinical sufferings ( 1). Notably, the significantly decreased neuronal activity in the decision related orbital middle frontal and anxiety-depression related lingual gyrus could be suggestive of reduced NSSI in adolescent MDD after therapy. The trend of upregulation of frontal neuronal activity and downregulation of occipital neuronal activity after sertraline treatment indicated that the therapy could be effective in regulating the abnormality. Also, depression severity was significantly decreased after treatment.Ĭonclusion: The abnormal functional neuronal activity found at frontal and occipital cortex implied cognitive and affective disturbances in adolescent nsMDDs. Further, whole brain comparison of mALFF at pre-treatment and post-treatment showed significantly decreased spontaneous activity in the orbital middle frontal and lingual gyrus in adolescent nsMDDs after treatment. Compared with the pre-treatment, the nsMDDs group was found to have a trend of, respectively, decreased and increased functional neuronal activity at the two brain areas after treatment through the region of interest analysis. Meanwhile, decreased mALFF was found in the medial superior frontal in adolescent nsMDDs compared with controls. Results: At pre-treatment, whole brain analysis of mean amplitude of low-frequency fluctuation (mALFF) was performed to examine the neuronal spontaneous activity alteration, and increased mALFF was found in the superior occipital extending to lingual gyrus in adolescent nsMDDs compared with controls. Besides the baseline scanning for all participants, the nsMDDs group was scanned again after eight weeks of sertraline therapy to examine the changes after treatment. The brain spontaneous activity alteration was then investigated in fifteen unmedicated first-episode adolescent nsMDDs versus twenty-two healthy controls through the resting-state functional magnetic resonance imaging. Methods: To verify the effectiveness and to explore the neurobiological processes, we treated a group of adolescents with nsMDDs with sertraline in this study. Studies have suggested that sertraline administration could be an effective way for treatment. However, the underlying neurobiological mechanism of NSSI in adolescents with MDD (nsMDDs) remains unclear, and there are still challenges in the treatment. 2Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chinaīackground: Non-suicidal self-injury (NSSI) commonly occurs among adolescents with major depressive disorder (MDD), causing adverse effects on the physical and mental health of the patients. ![]()
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